This Reprint brings together peer-reviewed contributions from the Special Issue Echocardiography and Cardiovascular Disease, showcasing current advances in cardiovascular ultrasound and its clinical impact. The presented articles address contemporary methods for image acquisition and quantification, including functional assessment, myocardial mechanics, and evaluation of structural and valvular heart disease. They also highlight how data-driven approaches can improve reproducibility, workflow efficiency, and risk stratification using routinely acquired echocardiographic data. By covering both methodological developments and practical clinical applications, this Reprint serve as a focused reference for clinicians, sonographers, researchers, and trainees who use echocardiography in the diagnosis, management, and longitudinal follow up of cardiovascular disease.