Drug-excipient-shell interactions using thermoplastic capsules

By Zdravka Misic

This book introduced novel starch-based thermoplastic capsules (S-PVA-Cs) and demonstrated their advantage over SGCs with respect to hydrophilic lipid-based formulations. Release studies in biorelevant media revealed differences in how formulations hydrated and interacted with the shell material. Drug-excipient-shell interactions were observed in various capsule types (SGCs, S-PVA-Cs, and VegaGels(R)) at different levels of biopharmaceutical in vitro testing. A better mechanistic understanding was attained that may guide future development of soft capsule products.

• Format: Paperback
• Language: English
• ISBN: 6202007141
• ISBN13: 9786202007146
• Release Date: September 2019
• Publisher: LAP Lambert Academic Publishing
• Length: 192 Pages
• Weight: 0.64 lbs.
• Dimensions: 0.4" x 6.0" x 9.0"