Drug-Drug Interactions

By A. David Rodrigues

Book Overview

Authored by renowned leaders in the field, this comprehensive volume covers all aspects of drug-drug interactions, including preclinical, clinical, toxicological, and regulatory perspectives.

Thoroughly updated, this second edition reflects the significant advances and includes extensive new material on:

key interplay between transporters and enzymes in drug metabolism and drug interactions the integral role of pharmacogenetics in metabolism-based drug-drug interactions in vivo - in vitro correlations (reversible, mechanism-based inhibition, induction) in silico approaches enabling structure-activity and structure-function studies high-throughput screening and GLP methods for evaluating drug interactions in vitro the use of transgenic animal models to evaluate drug interactions

Providing helpful case examples and computer-aided modeling, Drug-Drug Interactions is filled with over 200 invaluable tables, equations, and figures to clarify key concepts, and incorporates critical new updated information.

• Format: Paperback
• Language: English
• ISBN: 036745274X
• ISBN13: 9780367452742
• Release Date: December 2019
• Publisher: CRC Press
• Length: 768 Pages
• Weight: 2.23 lbs.
• Dimensions: 1.5" x 6.0" x 9.0"