DNA replication is an important part in the machinery of cell and viral proliferation. After significant advances in the past few years, its regulation is now more fully understood. This text provides a detailed and up-to-date review of the complexity of DNA replication in eukaryotic cells. It is organized into three parts. Concepts is a distillation of underlying principles, Proteins offers a description of each protein class involved, and Systems gives a review of events over a wide range of organisms.
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