Development of Lornxicam Microsponges Gel for Topical Application

By Anilkumar Shinde

The aim of the present study was to prepare microsponges gel formulation containing lornixicam by quasi emulsion solvent diffusion method. Lornoxicam is a Non-steroidal anti-inflammatory drug used for the treatment of various inflammatory diseases. Microsponges were spherical, uniform in shape, between 19 to 136μm in diameter. The production yield, actual drug content and encapsulation efficiency was found in the range of 57.14 0.47 to 88.57 0.799%, 54.78 0.76 to 83.55 0.65%, and 65.73 0.35 % to 95.04 0.42 respectively. The results of compatibility studies FTIR, PXRD, DSC and accelerated stability studies showed that no chemical interaction with drug and excipients. The dermal observation of skin irritation study shows no sign of either erythema or edema after 24 hrs of application. In % inhibition was more in microsponges gel as compare with pure drug gel in anti- inflammatory activity. Formulation of lornoxicam microsponges provides better control over release of drug. This study presents a new approach based on microsponge drug delivery system for topical application.

• Format: Paperback
• Language: English
• ISBN: 6202519193
• ISBN13: 9786202519199
• Release Date: April 2020
• Publisher: LAP Lambert Academic Publishing
• Length: 108 Pages
• Weight: 0.37 lbs.
• Dimensions: 0.3" x 6.0" x 9.0"