Development of a new generation of artificial heart valve

The project goal is minimizing life-threatening thrombo-emboli formation in pulsatile heart assist devices by a new biomimetic heart valve design based on metal-polymer composites. Heart prostheses support patients with late-stage heart diseases towards recovery or as a bridge to transplantation. In future, they will assist gene therapy to treat myocardial infarction. Besides of deficient blood flow (stagnant zones), state-of-the-art systems with mechanical valves generate platelet activating shear due to a narrow disc-ring gap. The novel composite and valve design solve these pressing medical needs: Injection moulding of polyurethane with a fragile titanium mesh insert combines biologically optimal micro-scale flexibility with macro-stiffness for mechanical function. Added transnational value is joining knowhow in: (1) heart valve design for optimal blood flow, (2) haemo-biofunctional coatings, (3) insert injection moulding, and(4) testing, finally on the artificial patient mode

• Format: Paperback
• Language: English
• ISBN: 6139975182
• ISBN13: 9786139975181
• Release Date: January 2020
• Publisher: LAP Lambert Academic Publishing
• Length: 60 Pages
• Weight: 0.22 lbs.
• Dimensions: 0.1" x 6.0" x 9.0"