Design Synthesis and Pharmacological Evaluation of Novel Phosphodiesterase FourInhibitors for their Anti Depressant and Anxiolytic Potential

By: Sudali, Muthu Venkatesh

Phosphodiesterase-4(PDE4), an important component of the cyclic adenosine

monophosphate (cAMP) cascade, selectively metabolizes cAMP in the brain to the

inactive monophosphate. Their inhibitors may offer novel strategies in the treatment of

depression. However, its development as antidepressant drugs has been encumbered

by their side effects profile of non-selective PDE inhibitors like nausea, emesis,

gastrointestinal...

• Format: Paperback
• Language: English
• ISBN: 2004059133
• ISBN13: 9782004059130
• Release Date: January 1
• Publisher: Rj Publishers
• Length: 294 Pages
• Weight: 0.87 lbs.
• Dimensions: 0.6" x 6.0" x 9.0"