This volume, LNCS 16607, constitutes the thoroughly refereed prototypes and research-in-progress proceedings of the 21st International Conference on Design Science Research in Information Systems and Technology, DESRIST 2026, which was held in M nster, Germany, during June 8-10, 2026. Given the large number of high-quality contributions, the 2026 proceedings are published in three volumes: LNCS 16605 and 16606 as main proceedings include all accepted full papers, while LNCS 16607 contains of accepted Prototypes and Research-in-Progress Proceeding papers. DESRIST 2026 received a total of 231 submissions across all tracks and formats. The 23 research-in-progress papers and 14 prototype papers included in this volume were carefully reviewed and selected from 89 submissions across these two categories. The papers as Prototypes and Research-in-Progress Proceeding papers presented in LNCS 16607 are organized in the following topical sections: Design for Better Futures: Beyond the Science of the Artificial (Theme Track); "From Insight to Impact" (General Track); The Future of Financial Services; Future of Data-Driven and AI-Enabled Design; Future of Healthcare and Wellbeing; Future of Design and Entrepreneurship; Future of Responsible and Sustainable Design; Future of Design Science Education; Future of Design Science Methodology; Future of Ecosystems for Design Science Research; Prototypes Track.
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