This Reprint brings together selected research articles from the Special Issue "Cutting-Edge Concepts in Knee Surgery" published in Medicina. It covers a broad range of contemporary topics in knee surgery, including joint preservation, ligament reconstruction, meniscal repair, and arthroplasty. The contributions address both technical and clinical dimensions of knee surgery, integrating biomechanical principles with patient-related factors and clinical outcomes. By presenting these perspectives together, the Reprint provides a balanced and clinically relevant overview of current approaches to knee interventions. This volume is intended as a practical reference for orthopedic surgeons and sports medicine specialists seeking evidence-based insights into modern knee surgery.