Coarse-Grained Modelling of DNA and DNA Self-Assembly

By Thomas E. Ouldridge

Book Overview

This thesis presents a novel coarse-grained model of DNA, in which bases are represented as rigid nucleotides. The model is shown to quantitatively reproduce many phenomena, including elastic properties of the double-stranded state, hairpin formation in single strands and hybridization of pairs of strands to form duplexes, the first time such a wide range of properties has been captured by a coarse-grained model. The scope and potential of the model is demonstrated by simulating DNA tweezers, an iconic nanodevice, and a two-footed DNA walker - the first time that coarse-grained modelling has been applied to dynamic DNA nanotechnology.

• Format: Paperback
• Language: English
• ISBN: 3642436528
• ISBN13: 9783642436529
• Release Date: August 2014
• Publisher: Springer
• Length: 176 Pages
• Weight: 0.60 lbs.
• Dimensions: 0.4" x 6.1" x 9.2"