Content ListSECTION 1: INTRODUCTION & FUNCTIONAL ANATOMY 1.1 Functions of the Respiratory System1.1.1 Gas exchange, acid-base balance, vocalization, defense1.1.2 Concept of respiration: external, internal, cellular1.2 Anatomy of the Respiratory Tract1.2.1 Upper and lower respiratory tracts1.2.2 Conducting vs. respiratory zones1.2.3 Alveoli: Type I and II cells1.2.4 Clinical Story: "The cough that never stopped: A case of bronchiolitis" SECTION 2: MECHANICS OF BREATHING 2.1 Lung Volumes and Capacities2.1.1 Tidal volume, inspiratory reserve, residual volume2.1.2 Vital capacity, FRC, TLC2.1.3 Spirometry and its clinical use2.2 Muscles of Respiration2.2.1 Inspiration: diaphragm, external intercostals2.2.2 Expiration: passive and active (abdominal, internal intercostals)2.3 Compliance and Elastic Recoil2.3.1 Lung compliance, chest wall compliance2.3.2 Hysteresis curve2.3.3 Diseases: emphysema vs. fibrosis2.4 Surfactant and Alveolar Stability2.4.1 Role of surfactant, synthesis by Type II cells2.4.2 Law of Laplace2.4.3 Neonatal respiratory distress syndrome (NRDS)2.5 Intrapleural Pressure and Pneumothorax2.5.1 Normal pressure gradients2.5.2 Pathophysiology of pneumothorax2.5.3 Spot exam: Pleural pressure tracing interpretation SECTION 3: VENTILATION 3.1 Pulmonary Ventilation3.1.1 Minute ventilation, alveolar ventilation3.1.2 Dead space: anatomical vs. physiological3.1.3 Fowler's and Bohr's methods3.2 Ventilation Distribution3.2.1 Regional differences in lung ventilation3.2.2 Effect of posture and gravity SECTION 4: DIFFUSION OF GASES 4.1 Alveolar-Capillary Gas Exchange4.1.1 Fick's law4.1.2 Diffusing capacity of the lungs (DLCO)4.1.3 Oxygen and carbon dioxide diffusion comparison4.2 Diffusion Impairments4.2.1 Fibrosis, edema, high altitude4.2.2 Exercise and pulmonary capillary reserve SECTION 5: PULMONARY BLOOD FLOW 5.1 Pulmonary Circulation5.1.1 Low pressure and high compliance5.1.2 Pulmonary vascular resistance5.2 Ventilation-Perfusion Ratio (V/Q) 5.3 Hypoxic Pulmonary Vasoconstriction SECTION 6: GAS TRANSPORT IN BLOOD 6.1 Oxygen Transport 6.2 Carbon Dioxide Transport SECTION 7: REGULATION OF RESPIRATION 7.1 Respiratory Centers 7.2 Chemoreceptor Regulation 7.3 Reflexes in Respiratory Control SECTION 8: ACID-BASE BALANCE & RESPIRATION 8.1 Buffer Systems in Blood 8.2 Respiratory Compensation 8.3 Clinical Scenarios SECTION 9: RESPIRATORY SYSTEM IN EXERCISE & ALTITUDE 9.1 Respiratory Adjustments in Exercise 9.2 Effects of High Altitude 9.3 Effects of Deep Sea Diving SECTION 10: RESPIRATORY PATHOPHYSIOLOGY (OVERVIEW) 10.1 Obstructive Lung Diseases 10.2 Restrictive Lung Diseases 10.3 Hypoxia 10.4 Respiratory Failure SECTION 11: EXAM PRACTICE ZONE 11.1 SEQs and Essay Model Answers11.2 Viva & OSCE Preparation SECTION 12: STORIES, MNEMONICS & DIAGRAMS 12.1 Clinical Stories 12.2 Mnemonics 12.3 Diagrams & Tables
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