When a negligent trucker causes an industrial accident and unleashes toxic waste on the insect population of Calico County with devastating results, Sheriff Wilbur Deeds has to deal with the mayhem created with the assistance of the National Guard and Dr Creed, a scientist who created the deadly chemical cocktail.
Faced with Chiggers growing physically at an alarming rate their intelligence is also growing too. Time is of the essence in order to stop the infestation, and hopefully stop the Matriarch laying more eggs. Hindered by the terrain and the devious methods of the creatures, the human element has to resort to using unconventional methods to defeat them.
Not only is the fate of the town and the local homesteads at risk but ultimately the rest of the world.