Chemical Biology of Nucleic Acids: Fundamentals and Clinical Applications

By Volker A. Erdmann

Book Overview

RNA as Major Components in Chemical Evolvable Systems - Peter Strazewski

How the Early Genetic Code Was Established? -Inference from the Analysis of Extant Animal Mitochondrial Decoding Systems - Kimitsuna Watanabe and Shin-ichi Yokobori

Isomerization of RNA Phosphodiester Linkages - Harri L?nnberg

Effects of Ionic Liquid and Liposomes on the Structure, Stability, and Function of Nucleic Acids - Naoki Sugimoto

Oxidative Damage on RNA Nucleobases - Pascal A. K?pfer and Christian J. Leumann

Use of FRET to Study Dynamics of DNA Replication - Philip Nevin and Penny J. Beuning

Design, Characterization, and Application of Imidazopyridopyrimidine: Naphthyridine Base-Pairing Motifs Consisting of Four Hydrogen Bonds - Noriaki Minakawa and Akira Matsuda

Creation of Unnatural Base Pair Systems Toward New DNA/RNA Biotechnologies - Michiko Kimoto and Ichiro Hirao

Flexible Nucleobase Analogues. Novel Tools for Exploring the Nucleic Acids - Sarah C. Zimmermann and Katherine L. Seley-Radtke

Sequence Selective Recognition of Double-Stranded RNA - Eriks Rozners

Determining Transient Nucleic Acid Structures by NMR - Jeetender Chugh

Diastereomer-Specific Repertoire of 7′R- or 7′S-Me-Carba-Locked Nucleic Acids (cLNAs) in Antisense Oligo/RNA Duplexes and Engineering of Physicochemical and Enzymological Properties -

Qing Li, Oleksandr Plashkevych, Ram Shankar Upadhayaya, Sachin Gangadhar Deshpande, Andras F?ldesi, and Jyoti Chattopadhyaya

Challenges and Opportunities for Oligonucleotide-Based Therapeutics by Antisense and RNA Interference Mechanisms - Ramon Eritja, Montserrat Terrazas, Santiago Grijalvo, Anna Avi??, Adele Alagia, S?nia P?rez-Rentero, and Juan Carlos Morales

Progress in Chemically Modified Nucleic Acid Aptamers - Masayasu Kuwahara

Aptamers as Molecular Smugglers - Eileen Magbanua and Ulrich Hahn

Biochemical Aspects of Subcellular RNA Transport and Localization - Diana Bauermeister, Maike Clau en, and Tomas Pieler

Small Size, Big Impact: Bacterial Functional Nucleic Acids and Their Applications - Wendy W.K. Mok, Simon A. McManus, and Yingfu Li

Towards Defined DNA and RNA Delivery Vehicles Using Nucleic Acid Nanotechnology - Anders Hauge Okholm, David Schaffert, and J rgen Kjems

Targeted Editing of Therapeutic Genes using DNA-Based Transcriptional Activators: Scope and Challenges - Ganesh N. Pandian and Hiroshi Sugiyama

Interaction of DNA Intramolecular Structures with Their Complementary Strands: A Thermodynamic Approach for the Control of Gene Expression - Irine Khutsishvili, Sarah E. Johnson, Calliste Reiling, Istok Prislan, Hui-Ting Lee, and Luis A. Marky

Site Directed Spin Labelling of RNA for Distance Measurements by EPR - Joachim W. Engels, Christian Gr?newald, and Lena Wicke

Chemo-Enzymatic Strategies to Modify RNA in vitro or in Living Cells - Daniela Schulz and Andrea Rentmeister

Metal Dependence of Ligand Binding and Heavy-Atom Derivatization of Evolutionarily Distinct PreQ1 Riboswitches - Joseph E. Wedekind, Joseph A. Liberman, Jermaine L. Jenkins, and Mohammad Salim

DNA G-Quadruplexes and I-Motifs in Therapeutics and Diagnostics - Yogini P. Bhavsar-Jog, Samantha M. Reilly, and Randy M. Wadkins

Peptides Targeting G-Quadruplex Structures - Kenji Usui and Arisa Okada

Synthesis of Site-Specifically Modified Long-Mer RNAs - Darko Balke, Jennifer Frommer, Nico Rublack, Danilo Springstubbe, Bettina Appel, and Sabine M?ller

Synthesis and Exon-Skipping Activity of Chemically-Modified RNAs - Yoshiaki Masaki, Takeshi Yamada, Hisao Saneyoshi, Akihiro Ohkubo, Kohji Seio, and Mitsuo Sekine

mRNA and snRNA Cap Analogs: Synthesis and Applications - Janusz Stepinski and Edward Darzynkiewicz

Innovative Chemistry for Synthesis of Regular RNA, 5'-Triphosphate RNA or 5'-Capped RNA - Yann Thillier, Fran?ois Morvan, Jean-Jacques Vasseur and Fran?oise Deb

• Format: Hardcover
• Language: English
• ISBN: 3642544517
• ISBN13: 9783642544514
• Release Date: May 2014
• Publisher: Springer
• Length: 599 Pages
• Weight: 2.20 lbs.
• Dimensions: 1.5" x 6.1" x 9.1"