This volume provides information on the wide spectrum of mechanisms which cells from simple prokaryotes to man use to respond to different forms of stress induced by chemicals, oxidants and DNA damaging agents. These mechanisms are fundamental to human health because they are crucial to the sensitivity of micro-organisms to chemotherapeutic agents, and they determine the sensitivity of normal and tumor cells to environmental agents and anti-cancer drugs. Research on these pathways is providing a wealth of new targets from which novel therapeutic agents are likely to emerge.
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