Guided Bone Regeneration (GBR) restores deficient alveolar bone to enable ideal prosthetic-driven dental implant placement. Grounded in Melcher's tissue-competition principles, GBR uses cell-occlusive membranes to block fast-growing soft tissues and allow slower osteogenic cells to regenerate bone. Within this isolated microenvironment, intramembranous ossification progresses from a blood clot into vascularized tissue, osteoid deposition, and mature lamellar bone. Clinical success relies on the PASS principles: primary wound closure, angiogenesis, space maintenance via bone grafts, and mechanical clot stability. Whether applied during socket preservation, simultaneous defect repair, or staged ridge augmentation, GBR ensures predictable long-term implant survival.
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