Bacterial Virulence Factors, Secretion of Virulence Protein

By Fanos Tadesse Woldemariyam

Bacterial cells must transport proteins across their membranes for the biogenesis of membranes and cell walls, motility and nutrient scavenging and uptake, and is also involved in pathogenesis and symbiosis. The translocase is an impressively dynamic nanomachine that is the central component which catalyses trans-membrane crossing. This complex, multi-stage reaction involves a cascade of inter- and intra-molecular interactions that select, sort and target polypeptides to the membrane, and in addition, transport through the outer membrane requires ATP or other sources of energy to promote the movement of these polypeptides across or their lateral escape and integration into the phospholipid bilayer, with high fidelity and efficiency. Here, the review addresses the structure and function of the translocase nanomachine and different mechanisms of protein secretion and their transport.The general secretion Sec and twin arginine translocation (Tat) pathways are the bacterial secretion systems most commonly used to transport proteins across the cytoplasmic membrane.Often, Sec or Tat systems transport unfolded and folded proteins first to the periplasmic space in Gram negative bacteria.

• Format: Paperback
• Language: English
• ISBN: 6200307725
• ISBN13: 9786200307729
• Release Date: September 2019
• Publisher: LAP Lambert Academic Publishing
• Length: 100 Pages
• Weight: 0.35 lbs.
• Dimensions: 0.2" x 6.0" x 9.0"