Applied Imaging in Systems Pharmacology

By Brian R Moyer, Immanuel Freedman, Peng Zou

This book reviews the role of pharmaco-imaging in drug development, in particular to instill the idea that modeling should lead to predictions that a candidate compound can be ruled in or out of an acceptable Clinical Target Product Profile (CTPP) based on clinical go / no-go criteria. Thus, the book drives a candidate drug or biologic's development via a process that gives a drug company a quantitatively-informed next step. Primarily, the chapters focus on actual drug company products where imaging played a role in the early and advanced development stages. The book has 10-15 examples of drug and biologic development models that use imaging to improve quantitative predictions and, in turn, better decisions.

• Format: Paperback
• Language: English
• ISBN: 1119459729
• ISBN13: 9781119459729
• Release Date: September 2022
• Publisher: Wiley
• Length: 432 Pages