Antisense Technology in the Central Nervous System

Bys: Leslie, Ronald A. and Hunter, A. Jackie

Book Overview

Antisense technology has been used for several years to knock down the expression of specific genes in living tissues to study the functions of their protein products. Specifically designed antisense oligonucleotides (ODNs) are short lengths of man-made genetic material designed to interfere with the production of the protein encoded by the gene. This can shed light on the function of the protein; alternatively, if a disease process results from an excess of a certain protein, the method can in theory correct the problem. Faster than transgenic techniques, but more problematic in practice, antisense has been seen as something of a black art. There are many technical problems to understand and overcome. This book provides a critical review of the uses of this technology in the central nervous system. It includes background to the technology problems of design and synthesis of antisense molecules administration in the brain protection of ODNs from metabolic destruction potential for CNS research and therapy. The text describes the promises and the pitfalls of this approach, and compares it to other approaches.

• Format: Hardcover
• Language: English
• ISBN: 0198503164
• ISBN13: 9780198503163
• Release Date: August 1999
• Publisher: Oxford Univ Pr
• Length: 250 Pages
• Weight: 1.30 lbs.
• Dimensions: 9.4" x 0.8" x 6.3"