Antibody-Drug Conjugates: The 21st Century Magic Bullets for Cancer (AAPS Advances in the Pharmaceutical Sciences Series)

Book Overview

.- I Introduction

.- 1 Antibody-Drug Conjugates: A Historical Review (Wei-Chiang Shen)

.- II The ADC Construct

.- 2 Payloads of Antibody-Drug Conjugates (Chalet Tan)

.- 3 Selecting an Optimal Antibody for Antibody-Drug Conjugate Therapy (Michael Ritchie, Laird Bloom, Gregory Carven, and Puja Sapra)

.- 4 Linker Design for Antibody-Drug Conjugates (E. Erica Hong and Ravi Chari)

.- III Development Issues

.- 5 Formulation Development for Antibody-Drug Conjugates (Junyan A. Ji, Jun Liu, Y. John Wang)

.- 6 Bioanalytical Assay for Characterization of Antibody Drug Conjugates (Chen Xie and Zhijun Wang)

.- 7 Pharmacokinetics/Pharmacodynamics and Disposition of Antibody-Drug Conjugates (Siddharth Sukumaran and Kedan Lin)

.- 8 Regulatory Considerations (Karen J. Cha)

.- IV Landscape, IP and Pharmacoeconomics

.- 9 Major ADC Companies, Current Clinical Trials, Recent Patents Issued and Patent Applications, and Cost Analysis of Drug Therapy (Jeffrey Wang and Jonathan H. Watanabe)

.- V Case Studies

.- 10 Mylotarg: Revisiting its Clinical Potential Post-Withdrawal (Jennica L. Zaro)

.- 11 ADCETRIS: A Regulatory Case Study of a New Generation Antibody Drug Conjugate (Bruce W. Hart Jr.)

.- 12 Ado-Trastuzumab Emtansine (Yun Luo, J?r?me J. Lacroix and Sunil Prabhu)

.- 13 The Antibody-Drug Conjugate Glembatumumab Vedotin (CDX-011) and its Use in Treatment of Breast Cancer (Nancy Chan and Linda T. Vahdat)

.- VI From Today to Tomorrow

.- 14 Summary and Future Directions (Jennica L. Zaro, Jeffery Wang and Wei-Chiang Shen).

• Format: Paperback
• Language: English
• ISBN: 3319376691
• ISBN13: 9783319376691
• Release Date: October 2016
• Publisher: Springer
• Length: 252 Pages
• Weight: 0.82 lbs.
• Dimensions: 0.6" x 6.1" x 9.2"