Antibacterial activity of Celecoxib

By Khouloud Kourimi, Nihal Khatoui, Farida Allal

Strategies for repositioning and forming eutectic mixtures by binary combination of Active Principle/Coformer or Active Principle/Active Principle are widely used to combat multi-resistant bacteria and increase solubility, bioavailability and consequently therapeutic effect. The choice of coformer is based on its chemical structure and the presence of proton-donating and proton-accepting functional groups capable of establishing non-covalent intermolecular interactions, such as hydrogen bonding, Van Der Waals forces and π-π interactions. The active ingredient chosen for repositioning is Celecoxib. The coformers are salicylic acid (A.SAL), maleic acid (A.MAL), nicotinamide (NIC), succinic acid (A.SUC) and cinnamic acid (A.CIN).

• Format: Paperback
• Language: English
• ISBN: 6208578124
• ISBN13: 9786208578121
• Release Date: January 2025
• Publisher: Our Knowledge Publishing
• Length: 60 Pages
• Weight: 0.21 lbs.
• Dimensions: 0.1" x 6.0" x 9.0"