Animal Models in Diabetes Research

Book Overview

Part I: Rodent Models of Type 1 Diabetes

1. The Non-Obese Diabetic (NOD) Mouse as a Model of Human Type 1 Diabetes

Kritika Kachapati, David Adams, Kyle Bednar, and William M. Ridgway

2. Assessment of Diabetic Nephropathy in the Akita Mouse

Jae-Hyung Chang and Susan B. Gurley

3. The BB Rat as a Model of Human Type 1 Diabetes

Rita Bortell and Chaoxing Yang

Part II: Rodent Models of Type 2 Diabetes

4. Diabetes in Mice with Monogenic Obesity: The db/db Mouse and Its Use in the Study of Cardiac Consequences

Darrell D. Belke and David L. Severson

5. Pathophysiology and Genetics of Obesity and Diabetes in the New Zealand Obese Mouse: A Model of the Human Metabolic Syndrome

Reinhart Kluge, Stephan Scherneck, Annette Sch?rmann, and Hans-Georg Joost

6. The TALLYHO Mouse as a Model of Human Type 2 Diabetes

Jung Han Kim and Arnold M. Saxton

7. Diet-Induced Diabetes in the Sand Rat (Psammomys obesus)

Nurit Kaiser, Erol Cerasi, and Gil Leibowitz

8. Diabetes in Zucker Diabetic Fatty Rat

Masakazu Shiota and Richard L. Printz

9. The GK Rat: A Prototype for the Study of Non-Overweight Type 2 Diabetes?

Bernard Portha, Marie-H?l?ne Giroix, Cecile Tourrel-Cuzin, Herv? Le-Stunff, and Jamileh Movassat

10. Experimentally Induced Rodent Models of Type 2 Diabetes

Md. Shahidul Islam and Rachel Dorothy Wilson

Part III: Other Species

11. Investigation and Treatment of Type 2 Diabetes in Nonhuman Primates

Barbara C. Hansen

Part IV: General Methodology

12. Determination of Beta-Cell Function: Insulin Secretion of Isolated Islets

Michael Willenborg, Kirstin Schumacher, and Ingo Rustenbeck

13. Determination of Beta-Cell Function: Ion Channel Function in Beta Cells

Martina D?fer

14. Measurement of Glucose Homeostasis In Vivo: Glucose and Insulin Tolerance Tests

Francesco Beguinot and Cecilia Nigro

15. Measurement of Glucose Homeostasis In Vivo: Combination of Tracers and Clamp Techniques

Masakazu Shiota

16. Measurement of Insulin Sensitivity in Skeletal Muscle In Vitro

Henrike Sell, J rgen Jensen, and Juergen Eckel

17. Beta-Cell Autoimmunity

Yannick F. Fuchs, Kerstin Adler, and Ezio Bonifacio

18. Positional Cloning of Diabetes Genes

Gudrun A. Brockmann and Christina Neuschl

19. Retinal Digest Preparation: A Method to Study Diabetic Retinopathy

Nadine Dietrich and Hans-Peter Hammes

20. Lineage Tracing of Pancreatic Stem Cells and Beta Cell Regeneration

Isabelle Houbracken, Iris Mathijs, and Luc Bouwens

21. Genetic Lineage Tracing of Beta Cell Neogenesis

Iris Mathijs, Isabelle Houbracken, and Luc Bouwens

Rita Bortell and Chaoxing Yang

• Format: Paperback
• Language: English
• ISBN: 1493962566
• ISBN13: 9781493962563
• Release Date: August 2016
• Publisher: Humana
• Length: 325 Pages
• Weight: 1.30 lbs.
• Dimensions: 0.7" x 7.0" x 10.0"