Since the Second World War a rapid development of 'Pharmaceutical chemicals', and ultimately drugs, has made a quantum progress. Drugs play a vital role in the progress of human civilization. The word "drug" has been derived from the French word "drogue", which means a "dry herbs". A very broad definition of a drug would include "all chemicals other than food that affect living processes." If the affect helps the body, the drug is a medicine. However, if a drug causes a harmful effect on the body, the drug is a poison. Medicinal chemists, pharmacologists, biochemists, analytical chemists and medical professionals have paved the way with their single goal objective to combat the sufferings of human beings. In this integrated effort the role of an analyst vis-a-vis the chemical purity of pharmaceutical substances and drugs made there from and finally the dosage forms that are usually available for direct patient's usage, has become not only extremely crucial but also equally important and vital. As on date, product safety has to be an integral part of all product research in pharmaceutical substances. However, the risk-beneft-ratio has got to be pegged to a bare minimum level. Therefore, it has become absolutely necessary to lay emphasis on product. Safety research and development which is very crucial in all the developmental stages of a new secondary pharmaceutical product.