Actin Polymerization in Apicomplexan: A Structural, Functional and Evolutionary Analysis

Book Overview

This book discusses in detail the structural, evolutionary and functional role of actin and its regulatory proteins in gliding motility in apicomplexan organisms, a unique phenomenon found in actin-myosin cytoskeletal elements.

The book also explores the potential of different actin regulators, namely formin, profilin, actin depolymerization factor (ADF), capping proteins (CPα and CPβ), cyclase-associated protein (CAP) and coronin 13-24 as potential drug targets against malaria. As the chief components of the gliding motor, the actin-regulator proteins are characterized by unique features that make them promising targets for structure-based drug design.

Lastly, the book proposes a mathematical model, based on kinetic data mining, to help understand the most vital regulators for actin polymerization dynamics.

• Format: Hardcover
• Language: English
• ISBN: 981137449X
• ISBN13: 9789811374494
• Release Date: November 2019
• Publisher: Springer
• Length: 101 Pages
• Weight: 0.75 lbs.
• Dimensions: 0.3" x 6.1" x 9.2"