β-Catenin, TCF, and ICAT

By Mohammad Zulfiquer Hossain

In addition to working together to drive expression of target genes, β-catenin and TCF often work independently of each other. They both regulate several stages of T cell development, but their mode of action remains poorly understood. To study the specific role of β-catenin-TCF interactions in T cells, we generated transgenic mice that express ICAT, a naturally occurring inhibitor of β-catenin-TCF interactions, in the T cell lineage. We found that β-catenin-TCF interactions are important for thymocyte survival, but not for proliferation or differentiation. Interestingly, thymocyte aging slows down in ICAT-Tg mice, suggesting a role for β-catenin-TCF interactions in normal thymic involution. We also discovered that β-catenin-TCF interactions provide survival signals to activated T cells and promote differentiation of activated CD4 T cells into the default Th2 lineage. However, TCF represses Th1 differentiation independently of its interaction with β-catenin. This study, thus, provides novel insights into the role of β-catenin and TCF in T cell development, function, and aging, and should of interest to immunologists, developmental biologists, and gerontologists alike.

• Format: Paperback
• Language: English
• ISBN: 3838334507
• ISBN13: 9783838334509
• Release Date: January 2010
• Publisher: LAP Lambert Academic Publishing
• Length: 196 Pages
• Weight: 0.65 lbs.
• Dimensions: 0.5" x 6.0" x 9.0"