The 5th IEEE International Conference on Applied System Innovation 2019 (IEEE ICASI 2019, https: //2019.icasi-conf.net/), which was held in Fukuoka, Japan, on 11-15 April, 2019, provided a unified communication platform for a wide range of topics. This Special Issue entitled "Selected Papers from IEEE ICASI 2019" collected nine excellent papers presented on the applied sciences topic during the conference. Mechanical engineering and design innovations...