The studies described in this book were carried out in the Mo- lecular Neurobiology Group, Department of Neurology, at the University of Diisseldorf, Germany. The main goal of this work was to gain an understanding of the mechanisms responsible for neuronal regeneration failure in the adult mammalian central nervous system and to learn how they can be influenced. Ap- proaches focused on (a) the identification of the extrinsic cellular and/or molecular...