Myeloid Leukemia: Methods and Protocols

By: Simon Goldhill

Book Overview

A panel of internationally recognized research scientists and clinical investigators brings together a diverse collection of readily reproducible methods for identifying and quantifying a large number of specific genetic abnormalities associated with the broad spectrum of myeloid malignancies. Highlights include techniques for the detection of BCR-ABL mutations and resistance to imatinib mesylate, detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia, classification of AML by DNA-oligonucleotide microarrays, and detection of the V617F JAK2 mutation in myeloproliferative disorders. In addition to gene rearrangments, other prognostically relevant molecular lesions such as FLT3 mutations and WT-1 overexpression are covered.

• Format: Hardcover
• Language: English
• ISBN: 1588294854
• ISBN13: 9781588294852
• Release Date: January 2006
• Publisher: Humana
• Length: 307 Pages
• Weight: 1.46 lbs.
• Dimensions: 1.1" x 7.0" x 9.3"