This Special Issue explores the transformative role of CBCT imaging in diagnosing and managing maxillofacial conditions. It highlights advancements in the use of CBCT for various applications, including the diagnosis of temporomandibular joint disorders and maxillofacial pathologies, as well as its role in facilitating precise surgical planning. This issue also features investigations into the accuracy of CBCT in detecting mandibular fractures and in dental implant planning, showcasing its critical role in trauma and rehabilitative dentistry. Recent studies further demonstrate CBCT's effectiveness in orthodontics, including the assessment of craniofacial anomalies and airway analysis, which contribute to comprehensive treatment strategies. The collection underscores CBCT's advantages in providing high-resolution, three-dimensional imaging with reduced radiation exposure compared to conventional CT, making it invaluable in clinical decision-making.