Additions to and Substitutions at C-C ?-Bonds (Comprehensive Organic Synthesis)

Volume 4 focuses on additions and the resulting substitutions at carbon-carbon &pgr;-bonds. Part 1 includes processes generally considered as simple polar reactions, reactive electrophiles and nucleophiles adding to alkenes and alkynes. A major topic is Michael-type addition to electron deficient &pgr;-bonds, featured in the first six chapters. In part 2 are collected the four general processes leading to nucleophilic aromatic substitution, including radical chain processes and transition metal activation through to &pgr;-complexation. Metal-activated addition (generally by nucleophiles) to alkenes and polyenes is presented in part 3, including allylic alkylation catalyzed by palladium. The coverage of nonpolar additions in part 4 includes radical additions, organometal addition (Heck reaction), carbene addition, and 1,3-dipolar cycloadditions.

• Format: Hardcover
• Language: English
• ISBN: 0080405959
• ISBN13: 9780080405957
• Release Date: February 1992
• Publisher: Pergamon
• Weight: 6.70 lbs.
• Dimensions: 10.8" x 2.8" x 7.5"